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Invitrogen™ E2F1 Monoclonal Antibody (16G7)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA531589
Description
Keep as concentrated solution. Positive Control: Jurkat.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Specifications
E2F1 | |
Monoclonal | |
1.86 mg/mL | |
PBS with no preservative | |
Q01094, Q61501 | |
E2F1 | |
The region encoding the DNA binding domain (amino acids 244-264) of E2F-1 expressed in E. coli. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG1 |
Immunoprecipitation, Western Blot, Immunocytochemistry | |
16G7 | |
Unconjugated | |
E2F1 | |
E2F transcription factor 1; E2F1; E2F-1; mKIAA4009; PBR3; PRB-binding protein E2F-1; RBAP1; RBAP-1; RBBP3; RBBP-3; RBP3; Retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; Transcription factor E2F1 | |
Mouse | |
Protein G | |
RUO | |
13555, 1869 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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