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Invitrogen™ E2F1 Polyclonal Antibody
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Catalog No. PIPA5142947
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100 μg
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PIPA5142947 100 μg
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Catalog No. PIPA5142947 Supplier Invitrogen™ Supplier No. PA5142947
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Description

Goat Polyclonal Antibody

Additional Information: Reported isoforms represent identical protein: NP_524437.2; NP_732646.1; NP_732647.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen E2F1
Applications Immunohistochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene E2F1
Gene Accession No. Q27368
Gene Alias E2F transcription factor 1; E2F1; E2F-1; mKIAA4009; PBR3; PRB-binding protein E2F-1; RBAP1; RBAP-1; RBBP3; RBBP-3; RBP3; Retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; Transcription factor E2F1
Gene Symbols E2F1
Host Species Goat
Immunogen Peptide with sequence C-TKGLFQTPYRSARN (aa 480-493).
Purification Method Ammonium Sulfate Precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 42550
Target Species Drosophila
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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