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E2F1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501980382
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100 μL
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Catalog No. Quantity
50-198-0382 100 μL
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Catalog No. 50-198-0382 Supplier Bioss Supplier No. BS0599R
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Description

Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Specifications

Antigen E2F1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene E2F1
Gene Accession No. Q01094
Gene Alias E2F transcription factor 1; E2F1; E2F-1; mKIAA4009; PBR3; pRB-binding protein E2F-1; RBAP1; RBAP-1; RBBP3; RBBP-3; RBP3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1
Gene Symbols E2F1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human E2F1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1869
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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