Invitrogen™ E2F2 Recombinant Rabbit Monoclonal Antibody (1H7D6)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538056

Catalog No. PIMA538056

Description

Positive Samples: HeLa, SH-SY5Y, Mouse lung, Mouse thymus Immunogen sequence: CPEEVQEPDS PSEEPLPSTS TLCPSPDSAQ PSSSTDPSIM EPTASSVPAP APTPQQAPPP PSLVPLEATD SLLELPHPLL QQTEDQFLSP TLA.

E2F2 is a member of the E2Ffamily of transcription factors. The E2F family plays a crucialrole in the control of cell cycle and action of tumor suppressorproteins and is also a target of the transforming proteins of smallDNA tumor viruses. The E2F proteins contain several evolutionallyconserved domains found in most members of the family. Thesedomains include a DNA binding domain, a dimerization domain whichdetermines interaction with the differentiation regulatedtranscription factor proteins (DP), a transactivation domainenriched in acidic amino acids, and a tumor suppressor proteinassociation domain which is embedded within the transactivationdomain. This protein and another 2 members, E2F1 and E2F3, have anadditional cyclin binding domain. This protein binds specificallyto retinoblastoma protein pRB in a cell-cycle dependent manner, andit exhibits overall 46% amino acid identity to E2F1.

Specifications

• Antigen: E2F2
• Classification: Recombinant Monoclonal
• Concentration: 1.1 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P56931, Q14209
• Gene Symbols: E2F2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 303-395 of human E2F2 (Q14209).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 1H7D6
• Conjugate: Unconjugated
• Gene: E2F2
• Gene Alias: E2F transcription factor 2; E2F2; E2F-2; LOW QUALITY PROTEIN: transcription factor E2F2; transcription factor E2F2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1870, 242705
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid