Invitrogen™ E2F3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106407

Catalog No. PIPA5106407

Description

Antibody detects endogenous levels of total E2F3.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.

Specifications

• Antigen: E2F3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: E2F3
• Gene Alias: DKFZp686C18211; E2F transcription factor 3; E2f3; E2F-3; E2f3a; E2F3b; KIAA0075; MGC104598; RGD1561600; RP1-177P22.2; Transcription factor E2F3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13557, 1871, 291105
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O00716, O35261
• Gene Symbols: E2F3
• Immunogen: A synthesized peptide derived from human E2F3(Accession O00716), corresponding to amino acid residues Y145-S195.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG