Invitrogen™ E2F6 Recombinant Rabbit Monoclonal Antibody (9I5M0)

Catalog No.	Quantity
PIMA537840	100 μL

Catalog No. PIMA537840 Supplier Invitrogen™ Supplier No. MA537840

Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: 293T, HepG2, RD Immunogen sequence: LDGIDLVEKK SKNHIRWIGS DLSNFGAVPQ QKKLQEELSD LSAMEDALDE LIKDCAQQLF ELTDDKENER LAYVTYQDIH SIQAFHEQIV IAVKAPAETR LDVPAPREDS ITVHIRSTNG PIDVYLCEVE QGQTSNKRSE GVGTSSSEST HPEGPEEEEN PQQSEELLEV SN.

This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.

Specifications

• Antigen: E2F6
• Applications: ChIP Assay, ELISA, Western Blot, CUT&RUN
• Classification: Recombinant Monoclonal
• Clone: 9I5M0
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 0.05% BSA and 0.02% sodium azide; pH 7.3
• Gene: E2F6
• Gene Accession No.: O75461
• Gene Alias: AI462434; E2F transcription factor 6; E2f6; E2F-6; E2F6b; E2F-binding site-modulating activity protein; EMA; MGC111545; Transcription factor E2F6; transcriptional repressor E2F6
• Gene Symbols: E2F6
• Host Species: Rabbit
• Immunogen: Recombinant Protein (or fragment).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1876
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG