Invitrogen™ E3L Polyclonal Antibody

Catalog No.	Quantity
FEPA5144504	100 μL

Catalog No. FEPA5144504 Supplier Invitrogen™ Supplier No. PA5144504

Description

Rabbit Polyclonal Antibody

E3L Polyclonal Antibody for ELISA, Western Blot

RNA-binding protein that plays a role in the inhibition of multiple cellular antiviral responses activated by double-stranded RNA (dsRNA), such as inhibition of PKR activation, necroptosis, and IFN-mediated antiviral activities. Recognizes and binds Z-RNA structures via its Z-binding domain and dsRNA via its DRBM domain: RNA-binding activity is required to escape host ZBP1-dependent necroptosis. Mechanistically, the Z-binding domain binds Z-RNAs that are produced during vaccinia virus infection, thereby competing with Z-RNA detection by host ZBP1, suppressing ZBP1-dependent necroptosis. Acts as a key inhibitor of the interferon response by blocking the phosphorylation and subsequent activation of IRF3 and IRF7 kinases that are required for interferon-alpha gene expression. Inhibits NF-kappa-B activation and the ubiquitin-like protein ISG15, which is an early antiviral protein. The binding with host ISG15 subsequently blocks host ISGylation.

Specifications

• Antigen: E3L
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 3.14 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
• Gene Alias: Protein E3
• Host Species: Rabbit
• Immunogen: Recombinant Vaccinia virus Protein E3 (E3L) (1-190AA).
• Purification Method: Protein A/G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Virus
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG