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Invitrogen™ E6AP Recombinant Rabbit Monoclonal Antibody (HL1660)
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Catalog No. PIMA547128
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100 μL
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PIMA547128 100 μL
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Catalog No. PIMA547128 Supplier Invitrogen™ Supplier No. MA547128
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Description

Rabbit Recombinant Monoclonal Antibody

Store as concentrated solution. Centrifuge briefly prior to opening vial.

UBE3A (ubiquitin-protein ligase E3A, AKA E6AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, UBE3A may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. UBE3A also plays an important role in the regulation of the circadian clock. Defects in UBE3A are a cause of Angelman syndrome (AS).
TRUSTED_SUSTAINABILITY

Specifications

Antigen E6AP
Applications Western Blot
Classification Recombinant Monoclonal
Clone HL1660
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene UBE3A
Gene Accession No. Q05086
Gene Alias 4732496B02; 5830462N02Rik; A130086L21Rik; ANCR; AS; CTCL tumor antigen se37-2; E6AP; E6-AP; E6-AP ubiquitin protein ligase; E6AP ubiquitin-protein ligase; EPVE6AP; FLJ26981; HECT-type ubiquitin transferase E3A; HPVE6A; human papilloma virus E6-associated protein; human papillomavirus E6-associated protein; mKIAA4216; oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54; UBE3A; ubiquitin conjugating enzyme E3A; ubiquitin protein ligase E3A; ubiquitin-protein ligase E3A
Gene Symbols UBE3A
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human UBE3A. The exact sequence is proprietary.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7337
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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