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Invitrogen™ EAAC1 Monoclonal Antibody (N180/41), FITC
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Catalog No. PIMA545548
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100 μg
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PIMA545548 100 μg
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Catalog No. PIMA545548 Supplier Invitrogen™ Supplier No. MA545548
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Description

Mouse Monoclonal Antibody

5 μg of MA5-45548 was sufficient for immunoprecipitation of EAAC1 from 50 μg of rat brain lysate. Detects approximately 60kDa. This antibody was formerly sold as clone S180-41.

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters. Four glutamate transporters have been identified: the sodium-dependent GLAST-1, GLT-1, EAAC-1 and the chloride-dependent EAAT-4. EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters are believed to include eight membrane-spanning alpha-helices and a loop-pore structure which is unique among secondary transporters but may resemble loop-pores found in ion channels. A second distinctive structural feature is the presence of a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane. Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity although no neurodegeneration was observed over a period of 12 months.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EAAC1
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N180/41
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS, 9.1mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
Gene Slc1a1
Gene Accession No. P43005, P51907
Gene Alias D130048G10Rik; DCBXA; EAAC1; EAAC2; EAAT3; excitatory amino acid carrier 1; excitatory amino acid carrier 2; excitatory amino acid transporter 3; excitatory amino acid transporter-3; excitatory amino-acid carrier 1; glutamate transporter mEAAC2; MEAAC1; Neuronal and epithelial glutamate transporter; REAAC1; SCZD18; SLC1A1; Sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 A1 (brain glutamate transporter); solute carrier family 1 member 1; solute carrier family 1, member 1
Gene Symbols Slc1a1
Host Species Mouse
Immunogen Fusion protein amino acids 1-524 (full length) of human EAAC1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25550, 6505
Target Species Human, Rat
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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