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Invitrogen™ EAAC1 Recombinant Rabbit Monoclonal Antibody (JU39-69)
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Catalog No. PIMA534614
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100 μL
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PIMA534614 100 μL
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Catalog No. PIMA534614 Supplier Invitrogen™ Supplier No. MA534614
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: Mouse liver tissue lysate, HUVEC, LOVO, SH-SY5Y, rat brain tissue, human tonsil tissue, human colon cancer tissue, human kidney tissue.Cell membrane.

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters. Four glutamate transporters have been identified: the sodium-dependent GLAST-1, GLT-1, EAAC-1 and the chloride-dependent EAAT-4. EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters are believed to include eight membrane-spanning alpha-helices and a loop-pore structure which is unique among secondary transporters but may resemble loop-pores found in ion channels. A second distinctive structural feature is the presence of a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane. Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity although no neurodegeneration was observed over a period of 12 months.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EAAC1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone JU39-69
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Slc1a1
Gene Accession No. P43005
Gene Alias D130048G10Rik; DCBXA; EAAC1; EAAC2; EAAT3; excitatory amino acid carrier 1; excitatory amino acid carrier 2; excitatory amino acid transporter 3; excitatory amino acid transporter-3; excitatory amino-acid carrier 1; glutamate transporter mEAAC2; MEAAC1; Neuronal and epithelial glutamate transporter; REAAC1; SCZD18; SLC1A1; Sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 A1 (brain glutamate transporter); solute carrier family 1 member 1; solute carrier family 1, member 1
Gene Symbols Slc1a1
Host Species Rabbit
Immunogen Recombinant protein within Human EAAT3 aa 80-209.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6505
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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