Eaat2 Polyclonal Antibody, Rockland™

Goat Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-1593	Rockland Immunochemicals 600101MN3	100 μg
50-199-1594	Rockland Immunochemicals 600101MN3S	25 μL

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against rat Eaat2. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to human, mouse, and rat.

Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.

Specifications

• Antigen: Eaat2
• Applications: ELISA, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Host Species: Goat
• Target Species: Mouse, Rat
• Gene Accession No.: P31596, P43006
• Gene ID (Entrez): 20511, 29482
• Primary or Secondary: Primary
• Product Type: Antibody

• Concentration: 1.05 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene Alias: 1700091C19Rik; 2900019G14Rik; AI159670; EAAT2; EAAT2 variant mEAAT2/5UT5; Excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; glial high affinity glutamate transporter; Glt; GLT1; GLT-1; GLT1a; GLT1b; GLT1c; glutamate transporter 1c; Glutamate/aspartate transporter II; GLUT-R; HBGT; high affinity glucose transporter; MGLT1; OTTHUMP00000165209; OTTHUMP00000165210; SLC1A2; Sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; Solute carrier family 1 member 2; solute carrier family 1, member 2
• Gene Symbols: SLC1A2
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: SLC1A2