Invitrogen™ EAPP Polyclonal Antibody

Catalog No.	Quantity
PIPA5143967	100 μg

Catalog No. PIPA5143967 Supplier Invitrogen™ Supplier No. PA5143967

Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human placenta tissue, human Hela whole cell, human COLO-320 whole cell, human Jurkat whole cell, human HEK293 whole cell, human K562 whole cell. IHC: human rectal cancer tissue, human rectal cancer tissue, human rectal cancer tissue, mouse cardiac muscle tissue. ICC/IF: Hela cell. Flow: HepG2 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

This protein may play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The C-terminal of EAPP binds the N-terminal of E2F1 and also interacts with E2F2 and E2F3, but not E2F4.

Specifications

• Antigen: EAPP
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene: EAPP
• Gene Accession No.: Q56P03, Q5BU09
• Gene Alias: 1810011O16Rik; BM036; BM-036; c14orf11; E2F associated phosphoprotein; E2F-associated phosphoprotein; Eapp; hypothetical protein LOC327318; RGD1309624; Unknown (protein for MGC:139672); wu:fd21g02; zgc:65820
• Gene Symbols: EAPP
• Host Species: Rabbit
• Immunogen: E.coli-derived human EAPP recombinant protein (Position: M1-S285).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55837, 66266
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG