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Invitrogen™ EAR2 Polyclonal Antibody
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Catalog No. PIPA534008
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50 μg
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PIPA534008 50 μg
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Catalog No. PIPA534008 Supplier Invitrogen™ Supplier No. PA534008
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Description

Rabbit Polyclonal Antibody

EAR2 Polyclonal Antibody for IHC (P)

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
TRUSTED_SUSTAINABILITY

Specifications

Antigen EAR2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene NR2F6
Gene Accession No. O09017, P10588, P43136
Gene Alias AV090102; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2; COUP transcription factor 3; COUPg; COUP-TF3; EAR2; EAR-2; Erba related 2; ERBAL2; ERBA-related gene-2; Nr2f6; Nuclear receptor subfamily 2 group F member 6; nuclear receptor subfamily 2, group F, member 6; nuclear receptor V-erbA-related; orphan nuclear receptor EAR-2; Ovalbumin upstream promoter gamma nuclear receptor; ovalbumin upstream promoter gamma nuclear receptor rCOUPg; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2; V-erbA-related protein 2; V-erbA-related protein EAR-2
Gene Symbols NR2F6
Host Species Rabbit
Immunogen Synthetic 16 amino acid peptide from ligand-binding domain of human NR2F6.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100296331, 100516724, 103163676, 13864, 2063, 245980, 609720
Target Species Human, Mouse, Rat, Canine, Monkey, Bovine, Hamster, Pig, Frog, Zebrafish, Bat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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