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Invitrogen™ EAR2 Polyclonal Antibody
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Catalog No. PA549785
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100 μL
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PA549785 100 μL
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Catalog No. PA549785 Supplier Invitrogen™ Supplier No. PA549785
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total EAR2 / NR2F6 protein.

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
TRUSTED_SUSTAINABILITY

Specifications

Antigen EAR2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene NR2F6
Gene Accession No. O09017, P10588, P43136
Gene Alias AV090102; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2; COUP transcription factor 3; COUPg; COUP-TF3; EAR2; EAR-2; Erba related 2; ERBAL2; ERBA-related gene-2; Nr2f6; Nuclear receptor subfamily 2 group F member 6; nuclear receptor subfamily 2, group F, member 6; nuclear receptor V-erbA-related; orphan nuclear receptor EAR-2; Ovalbumin upstream promoter gamma nuclear receptor; ovalbumin upstream promoter gamma nuclear receptor rCOUPg; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2; V-erbA-related protein 2; V-erbA-related protein EAR-2
Gene Symbols NR2F6
Host Species Rabbit
Immunogen Synthesized peptide derived from N-terminal of human NR2F6.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13864, 2063, 245980
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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