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Invitrogen™ ECE1 Monoclonal Antibody (303906)
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Catalog No. PIMA524015
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100 μg
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Catalog No. Quantity
PIMA524015 100 μg
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Catalog No. PIMA524015 Supplier Invitrogen™ Supplier No. MA524015
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Description

Rat Monoclonal Antibody

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Endothelin-converting enzyme 1 (ECE1) is located on chromosome 1p36.12 and encodes a zinc metalloprotease involved in the maturation of endothelin peptides, which are critical for vascular tone regulation and blood pressure control. ECE1 processes precursor proteins into active endothelins, particularly endothelin-1, the most potent vasoconstrictor known. This enzyme is expressed in multiple tissues, including endothelial cells, smooth muscle cells, and the central nervous system, where it participates in diverse physiological processes such as vasoconstriction, cell proliferation, and hormone secretion. Beyond its cardiovascular functions, ECE1 is implicated in neural development and neural crest cell migration. Dysregulation of ECE1 activity or endothelin signaling is associated with several pathologies, including hypertension, heart failure, and cancer progression due to its role in controlling vascular dynamics. Research into ECE1 aims to explore its therapeutic potential in managing cardiovascular disorders and its broader implications in systemic pathophysiology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ECE1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 303906
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene ECE1
Gene Accession No. P42892
Gene Alias AW322500; Ece; ECE 1; ECE1; ECE-1; ECE-1a; ECE-1b; ECE-1d; endothelin converting enzyme 1; endothelin-converting enzyme 1; endothelin-converting enzyme-1a; endothelin-converting enzyme-1b; endothelin-converting enzyme-1d
Gene Symbols ECE1
Host Species Rat
Immunogen Mouse myeloma cell line NS0-derived recombinant human ECE-1 Gln90-Trp770.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1889
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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