Invitrogen™ ECE1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110784

Catalog No. PIPA5110784

Description

Immunogen sequence: NEKVLTGYLN YMVQLGKLLG GGDEEAIRPQ MQQILDFETA LANITIPQEK RRDEELIYHK VTAAELQTLA PAINWLPFLN TIFYPVEINE SEPIVVYDKE YLEQISTLIN TTDRCLLNNY MIWNLVRKTS SFLDQRFQDA DEKFMEV.

Endothelin-converting enzyme 1 (ECE1) is located on chromosome 1p36.12 and encodes a zinc metalloprotease involved in the maturation of endothelin peptides, which are critical for vascular tone regulation and blood pressure control. ECE1 processes precursor proteins into active endothelins, particularly endothelin-1, the most potent vasoconstrictor known. This enzyme is expressed in multiple tissues, including endothelial cells, smooth muscle cells, and the central nervous system, where it participates in diverse physiological processes such as vasoconstriction, cell proliferation, and hormone secretion. Beyond its cardiovascular functions, ECE1 is implicated in neural development and neural crest cell migration. Dysregulation of ECE1 activity or endothelin signaling is associated with several pathologies, including hypertension, heart failure, and cancer progression due to its role in controlling vascular dynamics. Research into ECE1 aims to explore its therapeutic potential in managing cardiovascular disorders and its broader implications in systemic pathophysiology.

Specifications

• Antigen: ECE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ECE1
• Gene Alias: AW322500; Ece; ECE 1; ECE1; ECE-1; ECE-1a; ECE-1b; ECE-1d; endothelin converting enzyme 1; endothelin-converting enzyme 1; endothelin-converting enzyme-1a; endothelin-converting enzyme-1b; endothelin-converting enzyme-1d
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1889
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P42892
• Gene Symbols: ECE1
• Immunogen: Recombinant Protein corresonding to Human ECE1. Recombinant protein control fragment (Product #RP-99356).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov