Invitrogen™ ECE1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595430

Catalog No. PIPA595430

Description

Human ECE1 shares 94% and 93.5% amino acid (aa) sequence identity with mouse and rat ECE1, respectively. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: rat liver tissue, mouse heart tissue, mouse testis tissue, HELA whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Endothelin-converting enzyme 1 (ECE1) is located on chromosome 1p36.12 and encodes a zinc metalloprotease involved in the maturation of endothelin peptides, which are critical for vascular tone regulation and blood pressure control. ECE1 processes precursor proteins into active endothelins, particularly endothelin-1, the most potent vasoconstrictor known. This enzyme is expressed in multiple tissues, including endothelial cells, smooth muscle cells, and the central nervous system, where it participates in diverse physiological processes such as vasoconstriction, cell proliferation, and hormone secretion. Beyond its cardiovascular functions, ECE1 is implicated in neural development and neural crest cell migration. Dysregulation of ECE1 activity or endothelin signaling is associated with several pathologies, including hypertension, heart failure, and cancer progression due to its role in controlling vascular dynamics. Research into ECE1 aims to explore its therapeutic potential in managing cardiovascular disorders and its broader implications in systemic pathophysiology.

Specifications

• Antigen: ECE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ECE1
• Gene Alias: AW322500; Ece; ECE 1; ECE1; ECE-1; ECE-1a; ECE-1b; ECE-1d; endothelin converting enzyme 1; endothelin-converting enzyme 1; endothelin-converting enzyme-1a; endothelin-converting enzyme-1b; endothelin-converting enzyme-1d
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1889, 230857, 94204
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene Accession No.: P42892, P42893, Q4PZA2
• Gene Symbols: ECE1
• Immunogen: E.coli-derived human ECE1 recombinant protein (Position: M18-T233).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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