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Invitrogen™ EDA2R Polyclonal Antibody
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Catalog No. PA550400
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100 μL
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PA550400 100 μL
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Catalog No. PA550400 Supplier Invitrogen™ Supplier No. PA550400
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total EDA2R protein.

X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappa-B and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EDA2R
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 2.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene EDA2R
Gene Accession No. Q9HAV5
Gene Alias 9430060M22Rik; ectodysplasin A2 isoform receptor; ectodysplasin A2 receptor; EDA2R; EDA-A2 receptor; EDAA2R; EDA-A2R; RGD1564025; Tnfrsf27; Tumor necrosis factor receptor superfamily member 27; tumor necrosis factor receptor superfamily member XEDAR; UNQ2448/PRO5727/PRO34080; X linked ectodysplasin receptor; Xedar; X-linked ectodysplasin-A2 receptor
Gene Symbols EDA2R
Host Species Rabbit
Immunogen Fusion protein corresponding to residues near the C terminal of human ectodysplasin A2 receptor.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60401
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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