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Invitrogen™ EDA2R Polyclonal Antibody
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Catalog No. PIPA565878
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100 μL
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PIPA565878 100 μL
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Catalog No. PIPA565878 Supplier Invitrogen™ Supplier No. PA565878
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CQENEYWDQWG RCVTCQRCGP GQELSKDCGY GEGGDAYCTA CPPRRYKSSW GHHKCQSCIT CAVINRVQKV NCTATS Highest antigen sequence identity to the following orthologs - mouse 86%, rat 88%.

X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappa-B and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EDA2R
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene EDA2R
Gene Accession No. Q9HAV5
Gene Alias 9430060M22Rik; ectodysplasin A2 isoform receptor; ectodysplasin A2 receptor; EDA2R; EDA-A2 receptor; EDAA2R; EDA-A2R; RGD1564025; Tnfrsf27; Tumor necrosis factor receptor superfamily member 27; tumor necrosis factor receptor superfamily member XEDAR; UNQ2448/PRO5727/PRO34080; X linked ectodysplasin receptor; Xedar; X-linked ectodysplasin-A2 receptor
Gene Symbols EDA2R
Host Species Rabbit
Immunogen Recombinant Human EDA2R. Recombinant protein control fragment (Product #RP-106549).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60401
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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