EDG3 (extracellular) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA577744

Catalog No. PIPA577744

Description

Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 μL of deionized water.

EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.

Specifications

• Antigen: EDG3 (extracellular)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: S1PR3
• Gene Alias: S1PR3, Edg3, Lysophospholipid receptor 3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13610, 1903, 306792
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Flow Cytometry, Immunofluorescence, Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q99500, Q9Z0U9
• Gene Symbols: S1pr3
• Immunogen: Peptide (C)DYVGKLAGRLRD, corresponding to amino acid residues 23-34 of mouse Sphingosine 1-phosphate receptor 3
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG