Invitrogen™ EDG3 Recombinant Rabbit Monoclonal Antibody (5E3G9)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA537848

Catalog No. PIMA537848

Description

Positive Samples: HeLa, PC-3, Mouse lung, Mouse kidney, Mouse thymus, Rat lung, Rat spleen Immunogen sequence: MATALPPRLQ PVRGNETLRE HYQYVGKLAG RLKEASEGST LTTVLFLVIC SFIVLENLMV LIAIWKNNKF HNRMYFFIGN LALCDLLAGI AYKVNILMSG.

EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.

Specifications

• Antigen: EDG3
• Classification: Recombinant Monoclonal
• Concentration: 0.4 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q99500, Q9Z0U9
• Gene Symbols: S1PR3
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human S1PR3 (Q99500).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 5E3G9
• Conjugate: Unconjugated
• Gene: S1PR3
• Gene Alias: AI132464; cardiac sphingosine-1-phosphate specific receptor; EDG3; EDG-3; Edg3l; Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation sphingolipid G-protein-coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ37523; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; Lpb3; Lysophospholipid receptor B3; MGC71696; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; S1P receptor S1P3; S1p3; S1PR3; sphingosine; Sphingosine 1-phosphate receptor 3; sphingosine 1-phosphate receptor Edg-3; sphingosine-1-phosphate receptor 3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13610, 1903, 306792
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov