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Tocris Bioscience™ Eeyarestatin I
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Catalog No. 392210
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent inhibitor of ER-associated protein degradation and translocation

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquitinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA. Also enhances adeno-associated viral transduction in multiple cells types.

Chemical Identifiers

CAS 412960-54-4
Molecular Formula C27H25Cl2N7O7

Specifications

Quantity 10 mg
Formula Weight 630.44
Purity >98%
Chemical Name or Material Eeyarestatin I

Safety and Handling

Recommended Storage Desiccate at +4°C
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