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Invitrogen™ EFCAB4B Polyclonal Antibody
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Catalog No. PIPA585460
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100 μL
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PIPA585460 100 μL
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Catalog No. PIPA585460 Supplier Invitrogen™ Supplier No. PA585460
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Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Positive Control: A431. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EFCAB4B
Applications Western Blot
Classification Polyclonal
Concentration 0.56 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Cracr2a
Gene Accession No. Q9BSW2
Gene Alias Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; calcium release activated channel regulator 2A; calcium release-activated calcium channel regulator 2A; Calcium release-activated channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; Cracr2a; Efcab4b; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; Gm1073; Gm462; RGD1563719
Gene Symbols Cracr2a
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human EFCAB4B. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84766
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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