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Invitrogen™ EFCAB4B Polyclonal Antibody
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Catalog No. PIPA589473
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100 μL
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PIPA589473 100 μL
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Catalog No. PIPA589473 Supplier Invitrogen™ Supplier No. PA589473
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MAAPDGRVVS RPQRLGQGSG QGPKGSGACL HPLDSLEQKE TQEQTSGQLV MLRKAQEFFQ TCDAEGKGFI ARKDMQRLHK ELPLSLEELE DVFDALDADG NGYLTPQEFT TGFSHFFFSQ NNPSQEDAGE QVAQRHEEKV YLSRGDEDLG DMGEDEEAQF RMLMDRLGAQ KVLEDESDVK QLWLQLKKEE PHLLSNFEDF; Positive Samples: Mouse liver; Cellular Location: Cytoplasm.

CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EFCAB4B
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.01 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Cracr2a
Gene Accession No. Q3UP38, Q9BSW2
Gene Alias Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; calcium release activated channel regulator 2A; calcium release-activated calcium channel regulator 2A; Calcium release-activated channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; Cracr2a; Efcab4b; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; Gm1073; Gm462; RGD1563719
Gene Symbols Cracr2a
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CRACR2A (NP_0011384301).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 381812, 84766
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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