Invitrogen™ EFCAB4B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589473

Catalog No. PIPA589473

Description

Immunogen sequence: MAAPDGRVVS RPQRLGQGSG QGPKGSGACL HPLDSLEQKE TQEQTSGQLV MLRKAQEFFQ TCDAEGKGFI ARKDMQRLHK ELPLSLEELE DVFDALDADG NGYLTPQEFT TGFSHFFFSQ NNPSQEDAGE QVAQRHEEKV YLSRGDEDLG DMGEDEEAQF RMLMDRLGAQ KVLEDESDVK QLWLQLKKEE PHLLSNFEDF; Positive Samples: Mouse liver; Cellular Location: Cytoplasm.

CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Specifications

• Antigen: EFCAB4B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cracr2a
• Gene Alias: Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; calcium release activated channel regulator 2A; calcium release-activated calcium channel regulator 2A; Calcium release-activated channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; Cracr2a; Efcab4b; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; Gm1073; Gm462; RGD1563719
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 381812, 84766
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.01 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q3UP38, Q9BSW2
• Gene Symbols: Cracr2a
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CRACR2A (NP_0011384301).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG