Invitrogen™ EFHA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561023

Catalog No. PIPA561023

Description

Immunogen sequence: LAAAVAGAAL AGAGAAWHHS RVSVAARDGS FTVSAQKNVE HGIIYIGKPS LRKQRFMQFS SLEHEGEYYM TPRDFLFSVM FEQMERKTSV KKLTKKDIED TLSGIQT Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 76%.

Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.

Specifications

• Antigen: EFHA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MICU2
• Gene Alias: 09C01; 1110008L20Rik; 4833427E09Rik; AU041871; Calcium uptake protein 2, mitochondrial; EF hand domain family A1; EF hand domain family, member A1; EFHA1; EF-hand domain family member A1; EF-hand domain family, member A1; EF-hand domain-containing family member A1; Micu2; mitochondrial calcium uptake 2; RGD1309934; Smhs2; Smhs2 homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 221154
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IYU8
• Gene Symbols: MICU2
• Immunogen: Recombinant protein corresponding to Human EFHA1. Recombinant protein control fragment (Product #RP-97982).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG