Invitrogen™ EFHD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590128

Catalog No. PIPA590128

Description

Immunogen sequence: MATDELATKL SRRLQMEGEG GGETPEQPGL NGAAAAAAGA PDEAAEALGS ADCELSAKLL RRADLNQGIG EPQSPSRR; Positive Samples: Mouse lung; Cellular Location: Membrane raft.

EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLC-gamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-kappa-B-activating branch.

Specifications

• Antigen: EFHD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Efhd2
• Gene Alias: 2600015J22Rik; AA408606; D4Wsu27e; EF hand domain containing 2; EF hand domain family, member D2; EF-hand domain family member D2; EF-hand domain family, member D2; EF-hand domain-containing protein D2; Efhd2; MGC4342; RP3-467K16.3; swiprosin 1; swiprosin-1; Sws1; testicular tissue protein Li 62
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27984
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.48 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9D8Y0
• Gene Symbols: Efhd2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-78 of human EFHD2 (NP_0773052).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG