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Tocris™ EG 00229 trifluoroacetate
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Catalog No. 698610
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

EG 00229 trifluoroacetate is a neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.

Specifications

CAS 1210945-69-9
Quantity 10 mg
Solubility Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
Molecular Formula C17H19N7O5S3.CF3CO2H
Formula Weight 611.59
Product Type Antagonist
Purity 98%
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