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Invitrogen™ EGF Monoclonal Antibody (262930)
Rat Monoclonal Antibody
Supplier: Invitrogen™ MA523792
Description
In ELISAs, this antibody does not cross-react with recombinant mouse (rm) Amphiregulin, rmBetacellulin, rhEGF, rmEpigen, rmEpiregulin, rhHB-EGF, rhNRG-1 alpha, rhNRG1-beta 1, or rhTGF-alpha. Reconstitute at 0.5 mg/mL in sterile PBS.
EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
Specifications
EGF | |
Monoclonal | |
0.5 mg/mL | |
PBS with 5% trehalose and No Preservative | |
P01132 | |
EGF | |
E. coli-derived recombinant mouse EGF Asn977-Arg1029. | |
500 μg | |
Primary | |
Mouse | |
Antibody | |
IgG2a |
ELISA, Western Blot | |
262930 | |
Unconjugated | |
EGF | |
AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone | |
Rat | |
Protein A/G | |
RUO | |
13645 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
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