Invitrogen™ EGF Recombinant Rabbit Monoclonal Antibody (18B12)

Catalog No.	Quantity
FEMA550191	100 μL

Catalog No. FEMA550191 Supplier Invitrogen™ Supplier No. MA550191

Description

Rabbit Recombinant Monoclonal Antibody

EGF Recombinant Monoclonal Antibody for ELISA, Flow, IHC (P)

EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.

Specifications

• Antigen: EGF
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin)
• Classification: Recombinant Monoclonal
• Clone: 18B12
• Concentration: 1.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 0.05% BSA and 0.02% sodium azide; pH 7.4
• Gene: EGF
• Gene Accession No.: P01133
• Gene Alias: AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone
• Gene Symbols: EGF
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from Human EGF.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1950
• Target Species: Human
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG