Invitrogen™ EGFL6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114393

Catalog No. PIPA5114393

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human U-87MG whole cell, human A431 whole cell, human HL-60 whole cell, human K562 whole cell, human THP-1 whole cell, human Hela whole cell, rat liver tissue, mouse thymus tissue, mouse lung tissue, mouse liver tissue, mouse SP20 whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The EGFL6 gene encodes epidermal growth factor-like domain-containing protein 6, a member of the EGF-like repeat superfamily known for its roles in development and angiogenesis. EGFL6 is expressed at higher levels during embryonic development and has notable expression in various malignant tumors, highlighting its potential involvement in cancer progression. This secreted protein is pivotal in promoting tumor angiogenesis, influencing cancer cell migration and proliferation without affecting wound healing, making it a significant factor in tumor growth and metastasis. EGFL6 is also expressed in adipose tissues, and its role in adipose differentiation suggests it might link obesity to endometrial cancer risks. The protein impacts cellular activities such as cell adhesion, migration, and proliferation, contributing fundamentally to tumor dynamics. Consequently, EGFL6 is considered an attractive target for antibody-based therapies, with research evaluating its utility in cancer intervention strategies.

Specifications

• Antigen: EGFL6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EGFL6
• Gene Alias: EGF like domain multiple 6; EGF repeat-containing protein 6; EGFL6; EGF-like protein 6; EGF-like-domain, multiple 6; Epidermal growth factor-like protein 6; Maeg; MAM and EGF domain containing; MAM and EGF domains-containing gene protein; PP648; Protein W80; UNQ281/PRO320; W80
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25975, 317470, 54156
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: ELISA, Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene Accession No.: Q8IUX8, Q9JJZ5
• Gene Symbols: EGFL6
• Immunogen: E.coli-derived human EGFL6 recombinant protein (Position: K354-D535).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG