EGFR Antibody (DH8.3), PE/Atto594 - Mutant, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP250599PEATT594

Catalog No. N250599P594

Description

EGFR Monoclonal specifically detects EGFR in Human samples. It is validated for Flow Cytometry.

Specifications

• Antigen: EGFR
• Classification: Monoclonal
• Conjugate: PE/ATTO 594
• Formulation: PBS with 0.05% Sodium Azide
• Gene Symbols: EGFR
• Immunogen: Synthetic peptide corresponding to the junctional region of the truncated receptor LEEKKGNYVVTDHC,conjugated to keyhole limpet haemcyanin.
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: Clone DH8.3 of EGF R/ErbB1 antibody is specific for Truncated EGFR which is also called EGFR type III, EGFRvIII or delta-EGFR (characterized by a deletion of 267 amino acids in the extracellular domain, leading to a receptor which is unable to bind ligand yet is constitutively active). Because of its impaired internalisation and degradation, EGFRvIII is known to enhance tumourigenesis. NOTE: Clone DH8.3 DOES NOT cross-react with full length or wildtype EGFR (wtEGFR).
• Content And Storage: Store at 4°C in the dark. Do not freeze.

• Applications: Flow Cytometry
• Clone: DH8.3
• Dilution: Flow Cytometry
• Gene Alias: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10, EC 2.7.10.1, epidermal growth factor receptor, epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog), ERBB, ErbB1, ERBB1PIG61, HER1, mENA, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
• Host Species: Mouse
• Purification Method: Protein G purified
• Research Discipline: Cancer, Cell Biology, Cell Cycle and Replication, Cellular Markers, Cellular Signaling, Growth and Development, Hypoxia, Phospho Specific, Signal Transduction, Tumor Suppressors, Tyrosine Kinases
• Gene ID (Entrez): 1956.0
• Target Species: Human
• Isotype: IgG1