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Invitrogen™ EGFR (L858R Mutant) Recombinant Rabbit Monoclonal Antibody (RM380)
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Catalog No. PIMA544561
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100 μL
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PIMA544561 100 μL
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Catalog No. PIMA544561 Supplier Invitrogen™ Supplier No. MA544561
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Description

Rabbit Recombinant Monoclonal Antibody

EGFR (L858R Mutant) Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EGFR (L858R Mutant)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone RM380
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene EGFR
Gene Accession No. P00533
Gene Alias EGFR; Erbb1
Gene Symbols EGFR
Host Species Rabbit
Immunogen A peptide corresponding to human EGFR (L858R Mutant Specific). The immunogen range is a synthetic peptide within to amino acids 800-900 of EGFR with L858R mutant.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1956
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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