Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ EGLN1/EGLN2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109677

Catalog No. PIPA5109677


Only null left
Add to Cart

Description

Description

Immunogen sequence: DIRGDKITWI EGKEPGCETI GLLMSSMDDL IRHCNGKLGS YKINGRTKAM VACYPGNGTG YVRHVDNPNG DGRCVTCIYY LNKDWDAKVS GGILRIFPEG K.

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

EGLN1/EGLN2
Polyclonal
Unconjugated
Egln1
0610011A13Rik; AI503754; C1orf12; C85656; ECYT3; egl nine homolog 1; Egl nine homolog 2; egl nine-like protein 1; egl-9 family hypoxia inducible factor 1; egl-9 family hypoxia inducible factor 2; egl-9 family hypoxia-inducible factor 1; egl-9 family hypoxia-inducible factor 2; EGLN1; EGLN2; EIT6; EIT-6; Estrogen-induced tag 6; falkor; HALAH; HIF prolyl hydroxylase 2; HIF-1alpha prolyl-4-hydroxylase-1; Hif-p4h-1; Hif-p4h-2; HIFPH1; HIF-PH1; HIFPH2; HIF-PH2; HIF-prolyl hydroxylase 1; HIF-prolyl hydroxylase 2; HPH-1; HPH2; HPH-2; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 1; hypoxia-inducible factor prolyl hydroxylase 2; Ier4; immediate early response 4; ORF13; PHD1; PHD-1; PHD2; PHD-2; PNAS-118; PNAS-137; Prolyl hydroxylase domain-containing protein 1; prolyl hydroxylase domain-containing protein 2; SM20; SM-20; zinc finger MYND domain-containing protein 6; ZMYND6
Rabbit
Affinity Chromatography
RUO
112398, 54583
-20°C, Avoid Freeze/Thaw Cycles
Liquid
ELISA, Western Blot
0.81 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q96KS0, Q9GZT9
Egln1, EGLN2
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human EGLN1/EGLN2 (NP_0713341/NP_4442741).
100 μL
Primary
Human
Antibody
IgG
Product Suggestions

Product Suggestions

Videos
Safety and Handling

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.