EGR2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 134911AP150UL

Catalog No. 50-172-8782

Description

This antibody is a rabbit polyclonal antibody raised against a region of human EGR2.

The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are referred to as transcription factors. The early growth response 2 protein activates several genes that are involved in the formation and maintece of myelin, the fatty substance that covers and protects nerve cells. Myelin promotes the efficient transmission of nerve impulses. If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired. Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.

Specifications

• Antigen: EGR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EGR2
• Gene Alias: AT591, CMT1D, CMT4E, EGR 2, EGR2, KROX20, Zinc finger protein Krox 20
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114090, 13654, 1959
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.23 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P08152, P11161, P51774
• Gene Symbols: Egr2
• Immunogen: EGR2 Fusion Protein Ag4313
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG