Invitrogen™ EGR2b Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5143394

Catalog No. PIPA5143394

Description

Store as concentrated solution. Centrifuge briefly prior to opening vial. Positive control: 24 hpf zebrafish, 30 hpf zebrafish, 36 hpf zebrafish.

The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are referred to as transcription factors. The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the fatty substance that covers and protects nerve cells. Myelin promotes the efficient transmission of nerve impulses. If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired. Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.

Specifications

• Antigen: EGR2b
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Alias: AT591; CMT1D; CMT4E; DKFZp686J1957; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; early growth response 2; early growth response protein 2; Egr2; Egr-2; FLJ1454; FLJ14547; Krox20; Krox-20; Krox-20 homolog; KROX-20, Drosophila, homolog (early growth response-2); NGF1-B; OTTHUMP00000062133; Zfp-25; Zfp-6; Zinc finger protein Krox-20
• Immunogen: Recombinant protein encompassing a sequence within the center region of zebrafish Egr2b. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Target Species: Zebrafish
• Product Type: Antibody
• Isotype: IgG