Invitrogen™ EHD3 Polyclonal Antibody

Catalog No.	Quantity
PIPA5143924	100 μg

Catalog No. PIPA5143924 Supplier Invitrogen™ Supplier No. PA5143924

Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human placenta tissue, human A549 whole cell, human Hela whole cell, human CCRF-CEM whole cell, human U-87MG whole cell, human SY-SY5Y whole cell, monkey heart tissue, rat heart tissue, rat brain tissue, rat kidney tissue, rat liver tissue, mouse heart tissue, mouse brain tissue, mouse kidney tissue, mouse liver tissue. IHC: mouse brain tissue, human ovarian serous adenocarcinoma tissue, human ovarian serous adenocarcinoma tissue, human renal clear cell carcinoma tissue, human breast cancer tissue, human lung cancer tissue, human rectal cancer tissue, human gastric adenocarcinoma tissue, rat brain tissue. ICC/IF: MCF-7 cell. Flow: MCF-7 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The EHD3 gene encodes the EH-domain containing protein 3, part of the EHD protein family involved in the regulation of endocytic recycling and membrane trafficking. EHD3 plays a crucial role in the endosomal transport system, impacting how receptors and other membrane proteins are recycled back to the cell surface after internalization. This protein aids in maintaining cellular homeostasis by ensuring the efficient sorting and transport of cargo through the endosomal system. EHD3 has been implicated in various cellular functions, including insulin signaling, receptor recycling, and neuronal development, and significantly influences synaptic transmission and plasticity. Alterations in EHD3 expression or function can disrupt endosomal trafficking processes and are linked to conditions such as neurodegenerative diseases and cancer. Research on EHD3 is focused on uncovering its role in membrane dynamics and identifying potential therapeutic strategies for disorders involving dysfunctional endocytic pathways.

Specifications

• Antigen: EHD3
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and no preservative
• Gene: EHD3
• Gene Accession No.: Q8R491, Q9NZN3, Q9QXY6
• Gene Alias: EH domain containing 3; EH domain-containing protein 3; Ehd2; Ehd3; EH-domain containing 3; EH-domain containing protein 2; PAST homolog 3; PAST3; si:ch211-147c1.2
• Gene Symbols: EHD3
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence of human EHD3 (NELPAHLLPPSKRKVAE).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 192249, 30845, 57440
• Target Species: Human, Mouse, Monkey, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG