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Invitrogen™ EID1 Polyclonal Antibody
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Catalog No. PIPA5115165
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PIPA5115165 100 μL
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Catalog No. PIPA5115165 Supplier Invitrogen™ Supplier No. PA5115165
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total EID1.

E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EID1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene EID1
Gene Accession No. Q9Y6B2
Gene Alias 21 kDa pRb-associated protein; 2610002K20Rik; C15orf3; CREBBP/EP300 inhibitor 1; CREBBP/EP300 inhibitory protein 1; CRI1; E1A-like inhibitor of differentiation 1; EID; eid1; EID-1; EP300 interacting inhibitor of differentiation 1; EP300-interacting inhibitor of differentiation 1; IRO45620; NB4 apoptosis related protein; ORF12; PNAS-22; PTD014; Rb- and p300-binding protein EID-1; RBP21; retinoblastoma protein-associated protein; RGD1562702
Gene Symbols EID1
Host Species Rabbit
Immunogen A synthesized peptide derived from human EID1(Accession Q9Y6B2), corresponding to amino acid residues K72-Y122.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23741
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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