Invitrogen™ EID1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562322

Catalog No. PIPA562322

Description

Immunogen sequence: MSEMAELSEL YEESSDLQMD VMPGEGDLPQ MEVGSGSREL SLRPSRSGAQ QLEEEGPMEE EEAQPMAAPE GKRSLANGPN AGEQPGQVAG ADFESED Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 48%.

E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.

Specifications

• Antigen: EID1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EID1
• Gene Alias: 21 kDa pRb-associated protein; 2610002K20Rik; C15orf3; CREBBP/EP300 inhibitor 1; CREBBP/EP300 inhibitory protein 1; CRI1; E1A-like inhibitor of differentiation 1; EID; eid1; EID-1; EP300 interacting inhibitor of differentiation 1; EP300-interacting inhibitor of differentiation 1; IRO45620; NB4 apoptosis related protein; ORF12; PNAS-22; PTD014; Rb- and p300-binding protein EID-1; RBP21; retinoblastoma protein-associated protein; RGD1562702
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23741
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y6B2
• Gene Symbols: EID1
• Immunogen: Recombinant protein corresponding to Human EID1. Recombinant protein control fragment (Product #RP-98152).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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