EIF2S1 (phospho S51) Rabbit anti-Human, Clone:RM298, Abnova™

Rabbit monoclonal antibody raised against human EIF2S1 (phospho S51).

Supplier:  Abnova Corporation MAB16924

Catalog No. 89-333-271

Description

The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM]

Specifications

• Antigen: EIF2S1 (phospho S51)
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-200)
  Western Blot (1:100-200)
  The optimal working dilution should be determined by the end user.
• Gene: EIF2S1
• Host Species: Rabbit
• Quantity: 100 μL
• Test Specificity: This antibody reacts to human eIF-2α (eukaryotic translation initiation factor 2 subunit alpha) only when phosphorylated at Ser51. There is no cross-reactivity to eIF-2α not phosphorylated at Ser51. This antibody may also react to mouse or rat Phospho-eIF-2α (Ser51), as predicted by immunogen homology.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: RM298
• Description: eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
• Formulation: In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
• Gene Alias: EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
• Immunogen: A phospho-peptide corresponding to human EIF2S1 (phospho S51).
• Gene ID (Entrez): 1965
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG