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Invitrogen™ eIF3e Polyclonal Antibody
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Catalog No. PIPA529487
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100 μL
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PIPA529487 100 μL
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Catalog No. PIPA529487 Supplier Invitrogen™ Supplier No. PA529487
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Jurkat, Raji, BCL-1. Predicted reactivity: Mouse (100%), Xenopus laevis (97%), Chicken (96%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen eIF3e
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene EIF3E
Gene Accession No. P60228, P60229
Gene Alias 48kDa; eIF-3 p48; eIF3e; eIF3-p46; EIF3-P48; EIF3S6; eukaryotic translation initiation factor 3 subunit 6; Eukaryotic translation initiation factor 3 subunit E; eukaryotic translation initiation factor 3 subunit E isoform 2 transcript; eukaryotic translation initiation factor 3 subunit E-like protein; eukaryotic translation initiation factor 3, subunit 6 (48kD); eukaryotic translation initiation factor 3, subunit 6 48kDa; eukaryotic translation initiation factor 3, subunit E; eukaryotic translation initiation factor subunit E-like protein; Int6; mammary tumor integration site 6; mammary tumor-associated protein INT6; mammary tumor-associated protein INT-6; MMTV integration site 6; murine mammary tumor integration site 6 (oncogene homolog); NEWGENE_1311521; Viral integration site protein INT-6; viral integration site protein INT-6 homolog
Gene Symbols EIF3E
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human eIF3e. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16341, 3646
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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