Invitrogen™ eIF3e Recombinant Rabbit Monoclonal Antibody (3H4N2)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538067

Catalog No. PIMA538067

Description

Positive Samples: HeLa, 293T, Jurkat, Mouse lung, Mouse testis, Rat lung, Rat testis Immunogen sequence: QRTWLIHWSL FVFFNHPKGR DNIIDLFLYQ PQYLNAIQTM CPHILRYLTT AVITNKDVRK RRQVLKDLVK VIQQESYTYK DPITEFVECL YVNFDFDGAQ KKLRECESVL VNDFFLVACL EDFIENARLF IFETFCRIHQ C.

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.

Specifications

• Antigen: eIF3e
• Classification: Recombinant Monoclonal
• Concentration: 2 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P60228, P60229, Q641X8
• Gene Symbols: EIF3E
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 210-350 of human eIF3e (P60228).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 3H4N2
• Conjugate: Unconjugated
• Gene: EIF3E
• Gene Alias: 48kDa; eIF-3 p48; eIF3e; eIF3-p46; EIF3-P48; EIF3S6; eukaryotic translation initiation factor 3 subunit 6; Eukaryotic translation initiation factor 3 subunit E; eukaryotic translation initiation factor 3 subunit E isoform 2 transcript; eukaryotic translation initiation factor 3 subunit E-like protein; eukaryotic translation initiation factor 3, subunit 6 (48kD); eukaryotic translation initiation factor 3, subunit 6 48kDa; eukaryotic translation initiation factor 3, subunit E; eukaryotic translation initiation factor subunit E-like protein; Int6; mammary tumor integration site 6; mammary tumor-associated protein INT6; mammary tumor-associated protein INT-6; MMTV integration site 6; murine mammary tumor integration site 6 (oncogene homolog); NEWGENE_1311521; Viral integration site protein INT-6; viral integration site protein INT-6 homolog
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 103692906, 16341, 3646
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid