Invitrogen™ eIF3h Monoclonal Antibody (GT35512)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527798

Catalog No. PIMA527798

Description

Positive Control: A431 Predicted Reactivity: Rat (99%), Xenopus laevis (86%), Chicken (95%), Bovine (98%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

eIF3H is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Specifications

• Antigen: eIF3h
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: O15372, Q91WK2
• Gene Symbols: Eif3h
• Immunogen: Recombinant protein encompassing a sequence within the center region of human eIF3H/EIF3S3. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: GT35512
• Conjugate: Unconjugated
• Gene: Eif3h
• Gene Alias: 1110008A16Rik; 40 kDa; 40kD; 9430017H16Rik; eIF-3 gamma; eIF3 p40 subunit; eIF3 p40 subunit {ECO:0000255; eIF-3-gamma; eIF3-gamma; EIF3H; eIF3h {ECO:0000255; eIF3p40; eIF3-p40; EIF3S3; eukaryotic translation initiation factor 3 subunit 3; eukaryotic translation initiation factor 3 subunit 3 {ECO:0000255; eukaryotic translation initiation factor 3 subunit 3 gamma; eukaryotic translation initiation factor 3 subunit H; eukaryotic translation initiation factor 3 subunit H {ECO:0000255; eukaryotic translation initiation factor 3 subunit H-like protein; eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD); eukaryotic translation initiation factor 3, subunit 3 (gamma); eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD); eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa; eukaryotic translation initiation factor 3, subunit H; eukaryotic translation initiation factor subunit H-like protein; HAMAP-Rule:MF_03007}; MGC102958
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 68135, 8667
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid