eIF3h Polyclonal Antibody, Invitrogen™

Catalog No.	Quantity
PIPA596550	100 μL

Catalog No. PIPA596550 Supplier Thermo Scientific Supplier No. PA596550

Description

Rabbit Polyclonal Antibody

Immunogen sequence: NCFPFPQHTE DDADFDEVQY QMEMMRSLRH VNIDHLHVGW YQSTYYGSFV TRALLDSQFS YQHAIEESVV LIYDPIKTAQ GSLSLKAYRL TPKLMEVCKE KDFSPEALKK ANITFEYMFE EVPIVIKNSH LINVLMWELE KKSAVADKHE LLSLASSNHL GKNLQLLMDR VDEMSQDIVK YNTYMRNTSK QQQQKHQYQQ RRQQENMQRQ SRGEPPLPEE DLSKLFKPPQ PPARMDSLLI AGQINTYCQN IKEFTAQNLG K; Positive Samples: HT-29, HeLa, Jurkat, Mouse spleen, Mouse heart, Rat spleen; Cellular Location: Cytoplasm

eIF3H is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Specifications

• Antigen: eIF3h
• Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1.46 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene: Eif3h
• Gene Accession No.: O15372, Q6P9U8, Q91WK2
• Gene Alias: 1110008A16Rik, 40 kDa, 40kD, 9430017H16Rik, eIF-3 gamma, eIF3 p40 subunit, eIF3 p40 subunit {ECO:0000255, eIF-3-gamma, eIF3-gamma, EIF3H, eIF3h {ECO:0000255, eIF3p40, eIF3-p40, EIF3S3, eukaryotic translation initiation factor 3 subunit 3, eukaryotic translation initiation factor 3 subunit 3 {ECO:0000255, eukaryotic translation initiation factor 3 subunit 3 gamma, eukaryotic translation initiation factor 3 subunit H, eukaryotic translation initiation factor 3 subunit H {ECO:0000255, eukaryotic translation initiation factor 3 subunit H-like protein, eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD), eukaryotic translation initiation factor 3, subunit 3 (gamma), eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD), eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa, eukaryotic translation initiation factor 3, subunit H, eukaryotic translation initiation factor subunit H-like protein, HAMAP-Rule:MF_03007}, MGC102958
• Gene Symbols: Eif3h
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human EIF3H (NP_0037471)
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 299899, 68135, 8667
• Target Species: Human, Mouse, Rat
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov