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Invitrogen™ eIF4E Polyclonal Antibody
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Catalog No. PIPA577960
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100 μL
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PIPA577960 100 μL
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Catalog No. PIPA577960 Supplier Invitrogen™ Supplier No. PA577960
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Description

Rabbit Polyclonal Antibody

Positive Control: 293T, 293T cytoplasm fraction extract, mouse colon Predicted Reactivity: Rat (99%), Xenopus laevis (91%), Rabbit (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

eIF4E is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A, that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G.
TRUSTED_SUSTAINABILITY

Specifications

Antigen eIF4E
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.52 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Eif4e
Gene Accession No. P06730, P63073
Gene Alias AUTS19; CBP; EG668879; EIF4E; EIF-4E; EIF4E1; EIF4EL1; Eif4e-ps; EIF4F; eIF-4F 25 kDa subunit; eukaryotic translation initiation factor 4E; eukaryotic translation initiation factor 4E-like 1; eukaryotic translation initiation factor 4E-like protein; eukaryotic translation initiation factor 4-like protein; If4e; MGC111573; mRNA cap-binding protein; OTTHUMP00000219703; OTTHUMP00000219704; OTTHUMP00000219705; translation initiation factor eIF-4E
Gene Symbols Eif4e
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human eIF4E. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13684, 1977
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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