eIF4E Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-155-9396	Bethyl Laboratories, Inc A301154AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat, X. laevis, Bovine and Rabbit

All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A (see MIM 601102), that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G. (Rychlik et al., 1987 [PubMed 3469651]).

Specifications

• Antigen: eIF4E
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: Eukaryotic translation initiation factor 4E; eIF4E; eIF-4E; mRNA cap-binding protein; eIF-4F 25 kDa subunit; EIF4EL1; EIF4F
• Immunogen: Between 167 and 217
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: EIF4E

• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: P06730, P63073
• Gene ID (Entrez): 13684, 1977
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody