Invitrogen™ ELAC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106313

Catalog No. PIPA5106313

Description

Antibody detects endogenous levels of total ELAC2.

ELAC2 encodes a protein that has a C-terminal domain with tRNA 3 processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: ELAC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Elac2
• Gene Alias: 1110017O07Rik; COXPD17; D11Wsu80e; elaC homolog 2; elaC homolog 2 (E. coli); elaC homolog protein 2; elaC ribonuclease Z 2; ELAC2; elaC-like protein 2; ELC2; heredity prostate cancer protein 2; HPC2; putative prostate cancer susceptibility protein HPC2/ELAC2; ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z 2; tRNase Z(L); zinc phosphodiesterase ELAC protein 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 282826, 60528, 68626
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q80Y81, Q8CGS5, Q9BQ52
• Gene Symbols: Elac2
• Immunogen: A synthesized peptide derived from human ELAC2(Accession Q9BQ52), corresponding to amino acid residues H114-A164.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov