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Invitrogen™ ELK1 Recombinant Rabbit Monoclonal Antibody (10U8X1)
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Catalog No. PIMA535227
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100 μL
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PIMA535227 100 μL
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Catalog No. PIMA535227 Supplier Invitrogen™ Supplier No. MA535227
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: GGPGPERTPG SGSGSGLQAP GPALTPSLLP THTLTPVLLT PSSLPPSIHF WSTLSPIAPR SPAKLSFQFP SSGSAQVHIP SISVDGLSTP VVLSPGPQKP.

ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ELK1
Applications ELISA, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone 10U8X1
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.05% BSA and 0.02% sodium azide; pH 7.3
Gene ELK1
Gene Accession No. A4GTP4, P19419, P41969
Gene Alias ELK 1; ELK1; Elk-1; ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS transcription factor ELK1; ETS-like gene 1; Oncogene Elk1; tyrosine kinase (ELK1) oncogene
Gene Symbols ELK1
Host Species Rabbit
Immunogen Synthetic Peptide.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13712, 2002, 314436
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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