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ELK1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A303530A

Encompass_Preferred

Catalog No. 50-156-5388


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse

ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.
Specifications

Specifications

ELK1
Polyclonal
Unconjugated
ELK1
ETS domain protein Elk1, Oncogene Elk1
Rabbit
Antigen affinity chromatography
RUO
2002
4° C
Liquid
Immunoprecipitation, Western Blot
1 mg/ml
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
P19419
ELK1
Between 378 and 428
100 μL
Primary
Human
Antibody
IgG
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