Invitrogen™ ELL Monoclonal Antibody (OTI5E12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527365

Catalog No. PIMA527365

Description

ELL Monoclonal Antibody for Western Blot, IHC (P)

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. [UniProt].

Specifications

• Antigen: ELL
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P55199
• Gene Symbols: Ell
• Immunogen: Human recombinant protein fragment corresponding to amino acids 302-621 of ELL produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI5E12
• Conjugate: Unconjugated
• Gene: Ell
• Gene Alias: C19orf17; Eleven-nineteen lysine-rich leukemia protein; Ell; ELL gene (11-19 lysine-rich leukemia gene); ELL1; elongation factor for RNA polymerase II; elongation factor RNA polymerase II; hypothetical protein LOC325221; MEN; PPP1R68; protein phosphatase 1, regulatory subunit 68; RNA polymerase II elongation factor ELL; RNA POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN); wu:fc60b11; zgc:63836
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8178
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid