Invitrogen™ ELL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120451

Catalog No. PIPA5120451

Description

Positive test controls include: Mouse testis, Mouse liver. The target is usually found in the following locations: Cajal body, Nucleus, Nucleus speckle. Immunogen sequence: PAVNGKLGVP NGREALLPTP GPPASTDTLS SSTHLPPRLE PPRAHDPLAD VSNDLGHSGR DCEHGEAAAP APTVRLGLPL LTDCAQPSRP HGSPSRSKPK K.

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. [UniProt].

Specifications

• Antigen: ELL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ell
• Gene Alias: C19orf17; Eleven-nineteen lysine-rich leukemia protein; Ell; ELL gene (11-19 lysine-rich leukemia gene); ELL1; elongation factor for RNA polymerase II; elongation factor RNA polymerase II; hypothetical protein LOC325221; MEN; PPP1R68; protein phosphatase 1, regulatory subunit 68; RNA polymerase II elongation factor ELL; RNA POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN); wu:fc60b11; zgc:63836
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13716
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.9 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O08856
• Gene Symbols: Ell
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human ELL (NP_006523.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG